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Biopharma

Take your bioprocessing a step further with the FERMI SKID bioreactor

A holistic approach to custom process equipment for the biopharmaceutical sector — from conceptual design to manufacturing and qualification, with complete documentation.

  • Conceptual design and equipment manufacturing
  • Qualification: FAT and SAT
  • Comprehensive documentation

The FERMI SKID BF50Describe your process

An operator in a white coat at the FERMI SKID BF50 bioreactor in a clean room

Holistic approach

A holistic approach for biopharma

We give our clients a holistic approach to developing custom process equipment for the biopharmaceutical sector.

Every service is tailored to the client’s specific needs and specifications, and we support the whole process — from conceptual design to equipment manufacturing and qualifications such as FAT and SAT, together with comprehensive documentation.

  • Conceptual design
  • Equipment manufacturing
  • Qualification: FAT and SAT
  • Comprehensive documentation

The seven steps in detail

A RENI engineer in a white coat reviewing documents beside the bioreactor

FERMI SKID BF50

A breakthrough for bacteriophage production

As antibiotics face declining efficacy, the need for innovative solutions is vital. The BF50 is not just a bioreactor; it is an innovation — a self-contained unit for pilot-scale production and R&D laboratories.

  • Self-contained unit

    Integrated clean-in-place (CIP) and sterilise-in-place (SIP) systems keep hygiene optimal at every step. Purified water is dosed automatically, directly from the loop.

  • Clean room design

    Hygienic design starts with the exterior: the frame and cable trays create the conditions for a hygienic process, and the clean-design electrical cabinet completes it.

  • GMP-compliant software

    Fully GMP-compliant software with audit trails, archives and reports. Flexible recipe management makes the BF50 ideal for pilot-scale production and R&D laboratories.

  • Bottom-mounted magnetic agitator

    A bottom-mounted, magnetically coupled agitator mixes optimally, while digital load cells with capacitive technology and a hygienic design keep weighing precise in the clean room.

  • New-generation membrane valves

    A new generation of hygienic membrane valves accelerates CIP cycles, minimising downtime and maintenance.

  • CLIP ON temperature sensors

    CLIP ON sensors keep sterilisation under control without compromising hygiene. A pneumatic lid lift, CIP cleaning of the filter housings and a double filter group with automatic switchover complete the design.

The FERMI SKID BF50

Product lines

Systems for biopharmaceutical production

The FERMI SKID BF50 bioreactor, and the clean utilities, cleaning and transfer systems biopharmaceutical facilities run on.

Where bioprocessing matters

Relevant for different industries

  • Biotechnology

    Driving breakthroughs in molecular biology and genetics.

  • Pharmaceuticals

    Producing life-saving medicines, such as antibiotics and vaccines.

  • Food and beverages

    Improving food safety, flavour and shelf life.

  • Nutraceuticals

    Dietary supplements and food additives for global health.

  • Bioremediation

    Combating pollution and restoring ecosystems.

  • Probiotics

    Supporting gut health and overall well-being.

  • Cosmeceuticals

    Creating skincare formulations.

  • Chemicals

    Innovating sustainable chemical production.

  • Agriculture

    Higher crop yields with biofertilisers and biopesticides.

  • Biofuels

    Meeting renewable energy demand with biodiesel and bioethanol.

  • Animal health and nutrition

    Producing veterinary vaccines and supplements.

Reference project

Exothera: a new cGMP cell and gene therapy facility

The RENI installation in the Exothera facilityA RENI installer at work in the clean room

Biopharma · Exothera (Univercells)

A new cGMP cell and gene therapy facility and laboratories

Client
Exothera (Univercells)
Country
Belgium
Year
2020–2021
RENI’s scope
Engineering, equipment production, automation, on-site assembly, commissioning and qualification

The task

The client’s GMP facilities and laboratories, 5,500 m² in all, are in Belgium. Exothera is a CDMO and part of the Belgian Univercells group; it provides customised development of GMP processes and production services for gene therapy and viral-vector-based vaccines.

In 2020 Exothera started a project to establish new production facilities and laboratories. RENI’s multidisciplinary teams came together to provide a turnkey solution for the facility.

Outcome

Production and installation of a PW generation and distribution system, a compressor station, clean gas and purified water installations, clean room user points, and advanced hygiene and safety contamination installations. All solutions are integrated and automated in the new process; RENI took care of the entire installation on site, the safety plan and the qualification documentation.

Product lines in this project

Trusted by

Biotechnology companies on our reference list

  • Univercells

    Univercells

    A PW system with RO and EDI, process gases, user points and automation.

  • Exothera

    Exothera

    PW generation and distribution, clean gas and purified water installations and clean room user points for a new cGMP facility in Belgium.

  • Eurogentec

    Eurogentec

  • Medace

    Medace

All references

Describe your process

Which RENI system fits your process?

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  2. 2See the matching lines, references and the questions our engineers will ask.
  3. 3Check the pre-filled enquiry and send it — or change anything first.

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Project enquiry

Ready to take your bioprocessing to the next level?

Choose RENI as your partner in engineering bioprocesses. Tell us about your process, and we will show you how RENI can help you optimise your biomanufacturing.

Send a project enquiryCall +386 1 500 81 64

URS, P&ID or layout drawings: please send them by e-mail to info@reni.si